River of Flame (Act 4)Moving to Act 4, there aren't many waypoints that can be found in the area buy D2R ladder items. This makes establishing the best farming spots favorite spots a little more challenging. Thus, the majority of players go to The River of Flame as both an gold mine as well as the chance to test whether their characters are equipped to handle some of the most challenging encounters.
River of Flame has clustered monsters and lava that only Barbarian with Leap or an Sorceress who has Teleport access can use the advantage of. And, on top of that Hephasto the Armor constantly wants to take down players. If they manage to conquer these challenges, they'll be rewarded handsomely.
Chaos Sanctuary a.k.a. Diablo Run (Act 4)In the event that they don't gain anything substantial or desirable in the River of Flame, players can then proceed to the next big area which is Diablo's mainhold, Chaos Sanctuary. It also hosts several of the most powerful and most generous enemies in the game.
If the monsters aren't dropping something that is eye-catching, Diablo himself will surely do so. It's also helpful that Diablo isn't difficult to take down diablo II resurrected items. Diablo's savage attacks are easy to stay clear of and even the most budget-friendly Bonemancer build can take care of him.
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